"Kaiketsu Zorori Mahō Tsukai no Deshi Dai-Kaizoku no Takara-sagashi" centers on the mischievous yet endearing fox, Zorori, who aspires to become the "King of Pranks." Accompanied by his loyal boar companions, Ishishi and Noshishi, Zorori embarks on a new adventure after encountering a young girl named Popo, who claims to be the apprentice of a powerful magician. Popo seeks Zorori's help to find a legendary treasure hidden by a notorious pirate, which is said to grant immense power. The treasure hunt takes the group across diverse landscapes, from dense forests to treacherous seas, as they face various challenges, including rival treasure hunters and magical obstacles.

Throughout the journey, Zorori's cunning and resourcefulness are put to the test, often relying on his knack for pranks and quick thinking to overcome adversaries. Popo, despite her inexperience, demonstrates a growing mastery of magic, which proves crucial in navigating the dangers they encounter. Ishishi and Noshishi provide comic relief and unwavering support, often finding themselves in absurd situations due to Zorori's schemes. The narrative balances humor, adventure, and light-hearted moments, with occasional moral lessons about friendship, perseverance, and the consequences of one's actions.

The series introduces a colorful cast of characters, including the pirate captain who originally hid the treasure and his crew, who serve as recurring antagonists. Their motivations and backstories add depth to the treasure hunt, creating a dynamic interplay between the protagonists and their rivals. The story unfolds episodically, with each episode contributing to the overarching quest while maintaining a self-contained narrative structure. The blend of fantasy elements, such as magical artifacts and mythical creatures, with the whimsical tone of Zorori's antics, creates an engaging and accessible adventure suitable for a wide audience.