"Kill Me Baby" is a comedic slice-of-life anime centered around the daily lives of two high school girls, Yasuna Oribe and Sonya, whose contrasting personalities drive much of the humor. Yasuna is a cheerful and somewhat airheaded student, while Sonya is a stoic and serious transfer student from a foreign country, revealed to be a trained assassin. Despite their differences, the two form an unlikely friendship, though their interactions often escalate into chaotic and absurd situations.

The narrative unfolds through a series of episodic, self-contained skits that highlight the duo's misadventures. Yasuna frequently attempts to bond with Sonya, often ignoring or misunderstanding Sonya's lethal skills and dangerous background. Sonya, on the other hand, remains aloof and often responds to Yasuna's antics with physical violence, though her actions are played for comedic effect rather than genuine malice. The dynamic between the two is further complicated by Agiri Goshiki, a ninja classmate who occasionally joins their escapades, adding another layer of absurdity to the mix.

The humor in "Kill Me Baby" stems from the juxtaposition of mundane school life with the over-the-top elements of Sonya's assassin training and Agiri's ninja abilities. The series relies heavily on slapstick comedy, exaggerated reactions, and surreal scenarios, such as Sonya casually deflecting bullets or Agiri using ninja techniques for trivial tasks. Despite the frequent violence, the tone remains lighthearted, with no lasting consequences or serious stakes.

Supporting characters, including Yasuna's friend and classmate, Karin, and a talking bear named Unused Character, occasionally appear to contribute to the comedic chaos. The series does not follow a continuous plot but instead focuses on delivering quick, humorous vignettes that highlight the quirky personalities and interactions of the main cast. The lack of a overarching narrative allows for a flexible and episodic structure, making it easy to watch in any order.

Overall, "Kill Me Baby" is a straightforward comedy that thrives on its eccentric characters and their unpredictable, often nonsensical interactions. The series appeals to viewers seeking lighthearted, absurd humor with a touch of action and surrealism, all set against the backdrop of a seemingly ordinary high school environment.