"Anoyo no Subete wa, Obakegumi!" is a supernatural comedy anime that revolves around a group of eccentric ghosts and spirits who inhabit a mysterious, otherworldly realm. The narrative centers on their daily lives, interactions, and the peculiar challenges they face as supernatural beings. The main characters include a variety of yokai, each with distinct personalities and abilities, who form a loose-knit group known as the "Obakegumi."

The story unfolds in a whimsical, episodic manner, with each episode presenting self-contained scenarios that highlight the quirks and dynamics of the group. The leader of the Obakegumi is a mischievous yet charismatic ghost who often devises schemes to entertain themselves or solve minor conflicts within their realm. Other notable members include a shy yet powerful spirit with a penchant for causing accidental chaos, a grumpy yet loyal yokai who often serves as the voice of reason, and a playful, childlike ghost who brings levity to the group.

Throughout the series, the Obakegumi encounters various supernatural phenomena, from rival ghost factions to human intruders who stumble into their world. These encounters often lead to humorous misunderstandings, lighthearted conflicts, and occasional moments of camaraderie. The anime balances its comedic tone with subtle explorations of themes such as belonging, identity, and the nature of existence, as the characters navigate their roles as spirits in a world that is both familiar and strange.

The setting is a surreal, dreamlike version of the afterlife, filled with vibrant landscapes and fantastical elements that reflect the personalities and histories of its inhabitants. The interactions between the Obakegumi and the occasional human visitors provide a contrast between the mundane and the supernatural, often resulting in comedic or thought-provoking scenarios. The series maintains a lighthearted and accessible tone, making it suitable for a wide audience while offering a unique take on traditional yokai folklore.