"E's" is a 26-episode anime series that blends science fiction, psychological drama, and action. The story is set in a near-future world where a powerful organization named Ashurum controls society through advanced technology and psychic abilities. Ashurum, led by the enigmatic Chairman, seeks to harness and exploit individuals with psychic powers, known as "Gifted," for their own agenda. The series explores themes of power, control, and the ethical implications of manipulating human potential.

The protagonist, Kai Kudou, is a young man with a tragic past. After losing his family in a fire caused by Ashurum's experiments, Kai becomes a member of a resistance group called "E's," which opposes Ashurum's oppressive regime. E's is led by Yuuki Tokugawa, a skilled fighter and strategist, and includes other members such as Asuka Tokugawa, Yuuki's younger sister, and Ryuuji Yamagiwa, a former Ashurum operative. Together, they work to protect Gifted individuals and dismantle Ashurum's control.

Kai's journey is central to the narrative, as he grapples with his own psychic abilities and the trauma of his past. His powers, which initially manifest as uncontrollable bursts of energy, become a focal point for both E's and Ashurum. The Chairman, driven by a desire to create a new world order, sees Kai as a key to achieving his vision. This leads to intense confrontations between E's and Ashurum, with Kai often caught in the middle.

The series delves into the personal struggles of its characters, particularly Kai and Asuka. Asuka, who also possesses psychic abilities, faces her own challenges as she tries to reconcile her loyalty to E's with her growing feelings for Kai. Their relationship evolves amidst the chaos, adding emotional depth to the story. Meanwhile, Ryuuji's past as an Ashurum operative creates tension within the group, as his motivations and allegiances are frequently questioned.

Throughout the series, the conflict between E's and Ashurum escalates, culminating in a climactic showdown. The Chairman's true intentions are revealed, exposing the extent of his manipulation and the dark origins of Ashurum's experiments. The final episodes focus on Kai's internal struggle to control his powers and his determination to protect those he cares about, even at great personal cost.

"E's" combines action-packed sequences with introspective moments, creating a narrative that balances external conflict with internal growth. The series examines the consequences of wielding power and the importance of free will, making it a thought-provoking addition to the science fiction genre.