"Gakkō ga Kowai! Inuki Kanako Zekkyō Collection" is a horror anthology series based on the works of manga artist Inuki Kanako. The anime adapts a series of short, self-contained stories that revolve around supernatural occurrences, urban legends, and eerie phenomena, often set in schools or involving students. Each episode presents a standalone narrative, creating a collection of chilling tales that explore themes of fear, mystery, and the unknown.

The stories frequently feature ordinary students encountering bizarre and terrifying situations. For example, one tale involves a cursed game of hide-and-seek that leads to deadly consequences, while another explores a haunted classroom where a ghostly presence torments those who enter. The series delves into urban legends such as the "Red Room," where a mysterious online invitation leads to a horrifying fate, and the "Cursed Staircase," where a seemingly innocuous school staircase becomes a site of supernatural dread.

Characters in the series are typically students or teachers who find themselves entangled in these supernatural events. Their reactions range from skepticism to sheer terror as they confront the inexplicable. The narratives often build tension through atmospheric storytelling, with twists and unsettling conclusions that leave a lasting impression.

The anthology format allows for a diverse range of horror experiences, from psychological terror to visceral scares. The stories are united by their focus on school settings and the vulnerability of young protagonists, making the horror feel relatable and grounded. The series captures the essence of Inuki Kanako's manga, emphasizing the unsettling nature of everyday environments transformed by supernatural forces.