Bruno de Médicis serves as the noble head of the prestigious de Médicis family within the San Fleuve Empire. He possesses blond hair and blue eyes, typically dressing in formal attire like a navy jacket, light brown vest, navy pants, and black boots, reflecting his status as an archduke and royal court pharmacist. Professionally, Bruno acts as principal of the Imperial Medical School (later the Imperial Medical and Pharmaceutical Academy) and holds the distinction of being one of only three royal court pharmacists in the empire. His expertise allows him to diagnose diseases such as tuberculosis, known as "white death" or "white sickness," using observational methods despite the era's technological constraints. He contracts tuberculosis while treating Empress Elisabeth II but is cured by medicine developed by his son, Farma. Following his recovery, he receives the appointment of governor of the port region of Marseirre. Bruno wields water-attribute divine arts, enabling him to manipulate water and ice for both medical purposes and combat, utilizing techniques like his "ice sword dance." As a pharmacist, he emphasizes compassion and attentive patient care above mere technical skill, often instructing, "Don’t look for knowledge only in books! Look closely at your patients!" He instills these values in his family, conducting surprise pharmacology quizzes during meals. Initially, Bruno maintains a stern and demanding relationship with his son Farma, subjecting him to rigorous training to prepare him for pharmacy. After Farma is struck by lightning and possessed by the reincarnated soul of pharmacologist Kanji Yakutani, Bruno remains distrustful of his son's altered behavior and unconventional methods. This tension peaks during Empress Elisabeth's tuberculosis crisis when Bruno attempts to stop Farma from treating her, believing the proposed medicine to be poison. However, after Farma demonstrates the scientific basis for his treatment and successfully cures both Bruno and the Empress, Bruno accepts Farma's abilities and secrets. Their relationship evolves into one of mutual respect and collaboration, with Bruno supporting Farma's efforts to reform healthcare accessibility. Bruno shares a loving marriage with Béatrice de Médicis and is a protective father to his children, including daughter Blanche and eldest son Palle. He expresses pride in Palle's pharmacological studies but disapproves of Palle's harsh training methods toward Farma and Blanche. Bruno also maintains a collegial rivalry with fellow pharmacist Camus de Sade, which turns to horror and regret upon the revelation of Camus's unethical human experiments; Bruno later wishes he had eliminated Camus earlier. During the Black Death epidemic, Bruno leverages his authority to aid Farma's relief efforts when traditional guilds obstruct them. He confronts Camus during an attack on Farma's pharmacy, physically battling him while Farma treats the wounded.