Queen Elisabeth II, Empress of the San Fleuve Empire, ascended to the throne at seventeen after her father's death from illness. She has ruled for seven years, later contracting tuberculosis—termed the "white death" in her realm. Her appearance features white hair styled in a Dutch bun for court, piercing red eyes, and elegant red-and-white robes with gold trim. She adorns herself with a prominent necklace, exquisite earrings, and opera gloves, often depicted amid roses to accentuate her regal aura. Personally charismatic and a strong leader, she privately doubts her capability, especially after falling ill. Her resolve fortifies through devotion to her young son, Louis. A bold impulsiveness surfaces when she challenges protagonist Farma de Médicis to a throne duel, which he declines. Her transformation begins when Farma diagnoses and cures her tuberculosis, using modern pharmaceutical knowledge and a microscope to reveal the bacterial cause to the court. Witnessing Farma consume the medication to prove its safety cements her trust in him. Grateful, she grants him honors, resources, and authority to establish a pharmacy providing affordable healthcare for commoners, directly opposing the monopolistic Pharmacist Guild. Beyond political alliance, she grows fond of Farma, recognizing his otherworldly origins and valuing his loyalty. Their bond includes intimate moments like private bathing in a thermae, hinting at romance. She sponsors artist Charlotte "Lotte" Soller after commissioning paintings from her, supporting new talent once her previous artist retires due to failing eyesight. Her divine abilities focus on fire manipulation, though an incomplete holy crest limits her power. She remains a foremost practitioner of divine arts. During crises like the Black Death pandemic, she collaborates with Farma and Bruno de Médicis, leveraging imperial authority to contain outbreaks despite guild opposition. Later, she witnesses Farma’s sacrifice during the "Dark Eclipse," where he expends his divine powers to protect the empire. Though the aftermath resets some world elements, her reforms—including accessible medicine—endure. Trivia notes include her penchant for surprising Farma with unexpected rewards and her continued patronage of her former artist’s abstract works, appreciating the distorted perspective from his deteriorating vision.