The anime *Sekigahara Gassen: Kiro ni Tatta Tarui no Bushō-tachi* references Yoshitsugu Ōtani in one source. Available information centers on his historical background, struggle with illness, pivotal role at the Battle of Sekigahara, and relationships with figures like Ishida Mitsunari and Tōdō Takatora. His depictions extend to game series such as *Samurai Warriors* and *Sengoku BASARA*.