Nobuko Hyakumura practices comedy skits with her partner Yuu Kuroo on the school roof when the zombie outbreak traps them and other survivors. Within the group, she provides comedic relief, using humor as a coping mechanism during the dire circumstances. Her foundational comedic partnership with Yuu frames their interactions throughout the chaos.

Her character development focuses on adapting to the survival scenario. She shifts from reliance on humor toward demonstrating increasing determination to endure the threats alongside fellow students. Her pivotal relationship with Yuu offers mutual support as they navigate the overrun school. She evolves from initial panic to active participation in group efforts to evade the zombies.