In the anime Tom to Jerry Gokko, Jerry is presented as a cute but clever mouse, reimagined for a lighter and softer interpretation of the classic slapstick comedy. His design embodies the series super-deformed, kawaii aesthetic with a larger head, softer features, and a bright, pastel color palette, making him appear younger and more adorable than his traditional counterpart. Despite this gentler visual approach, Jerry retains the core intelligence and resourcefulness that defines his character. His primary motivation for his constant conflicts with Tom is often food-related, and he is presented as a frequent and unrepentant food thief who regularly targets Tom various endeavors, such as his food truck or bakery. This gluttonous tendency is shared with his young companion, Tuffy, and often serves as the catalyst for the episode antics.

Jerry role in the story revolves around his dynamic with Tom. While their relationship is fundamentally a rivalry built on chasing and pranks, the series often implies a friendly rivalry, with several episodes ending with the two characters laughing and having fun together. However, this does not diminish Jerry protectiveness or his willingness to retaliate. The series portrays him as a Papa Wolf figure who is fiercely protective of Tuffy; when Tom accidentally hurts the young mouse, Jerry becomes intensely angry and is unafraid to confront the cat directly to defend him. Jerry also takes on the role of a leader and role model for Tuffy, who follows his example in mischief and escapades. While Tom is often the butt of the joke, Jerry is not a Karma Houdini in this iteration, as he sometimes faces repercussions for his own unprovoked harassment of the cat.

A notable ability unique to this version of the character is the power of transformation. When Jerry eats a large piece of food, he can take on the shape of that item. For instance, after consuming an entire piece of cheese, his body contorts into the form of the cheese itself, a direct reference to a famous moment from the original shorts. He is also seen taking on the form of other foods he eats whole, such as an apple. This ability adds a fantastical and playful element to the series and distinguishes this Jerry from previous incarnations. Throughout the series, interactions with the wider cast are minimal, but recurring figures like the duck Quacker and the dog Spike appear in certain episodes, such as Easter and birthday specials, where Jerry participates in preparing surprises or finding special eggs.