Misa Tokiwa is a supporting character in the anime My Brother's Wife. She is the younger sister of Miwa Karaki, who is married to Satoshi Kagura. Misa is a young woman attending college, where she often highlights her popularity among her peers. Physically, she has brown hair and brown eyes.

Her background places her as part of the extended family circle that revolves around the Kagura household. Misa has known Takashi Kagura, her sister's brother-in-law, for some time and harbors a long-standing romantic attachment to him. However, she consistently denies these feelings, choosing instead to emphasize her social success at school and maintain a defensive, casual attitude.

Misa's personality is characterized by a blend of persistence and denial. She follows Takashi closely and seeks his attention, yet she deflects any suggestion of deeper emotion. This contradiction drives her behavior throughout the story. Her motivations stem from a genuine but unacknowledged love for Takashi, as well as a desire to assert her own identity separate from her older sister.

Her role in the story is that of a secondary love interest and a complicating factor in the strained relationships between Takashi, his brother Satoshi, and Miwa. As the narrative progresses, Misa becomes more directly involved in the emotional and physical tensions of the household, eventually joining the complicated dynamic between the characters.

In terms of development, Misa transitions from a relatively peripheral figure acting on unspoken feelings to someone who actively participates in the central conflicts, though her growth remains tied to her pursuit of Takashi and her rivalry with Miwa. She does not display any supernatural or extraordinary abilities; her notable traits are her persistence, her denial, and her social confidence as a college student.