Kurisu Makise, a neuroscientist renowned for pioneering advancements in cognitive science and memory digitization, emerges from a legacy of scientific ambition. Born to physicist Shouichi Makise, her prodigious intellect surfaced early; by age 11, she challenged her father’s theories, straining their relationship. Graduating from an American university at 14, she joined Viktor Chondria University’s Brain Science Institute, collaborating with Maho Hiyajo and Alexis Leskinen on the Amadeus project—an AI replicating human cognition through pre-2010 memory data, including her own. Her personality blends razor-sharp wit with guarded vulnerability, cloaking emotions in sarcasm and logical pragmatism. Initially dismissive of time travel, she later spearheads experiments to shift worldlines. A tsundere dynamic defines her relationship with Rintaro Okabe, marked by spirited debates and unspoken affection beneath their rivalry. In beta worldline narratives, her physical death during a confrontation over her father’s research ignites pivotal events. The Amadeus AI, her digital replica, retains her memories and personality but lacks post-March 2010 experiences. This self-aware entity collaborates with Okabe and Maho to avert global conflict, strategizing worldline manipulations while confronting existential purpose. Expanded media highlight her cross-temporal influence. The film *Load Region of Déjà Vu* depicts her aiding Okabe’s resurgence through time travel, deepening their bond. She mentors Mio Kunosato in *Chaos;Child* and appears in *Robotics;Notes DaSH* as "KuriGohan and Kamehameha," debating technology and conspiracies online. Her signature attire merges academic rigor and nostalgia: a khaki jacket, red tie, and Okabe-gifted lab coat over a uniform-inspired ensemble. Visual portrayals alternate between chestnut and red hair, echoing the "chestnut" root of her name. Pseudonymous forum activity reflects longing for Japan during U.S. residency. Despite acclaim, she navigates paternal resentment and the tension between scientific drive and emotional ties. In *Steins;Gate 0*, her legacy fuels explorations of AI ethics and causality. The Amadeus iteration confronts existential limits, opting for self-deletion to thwart data exploitation—a final act underscoring themes of identity and sacrifice.