Megami-sama, a divine entity, bestows transformation powers upon Tukishima Moe, enabling her to become a magical girl. This power equips Moe to safeguard Akihabara, the source of moe energy, from falling into evil hands. The transformation item provided by Megami-sama allows Moe to battle rival magical girls using English chants. Moe's initial struggles with English necessitate training, involving characters like Emily to prepare her. Megami-sama's ultimate goal is Moe's readiness for a final battle in 50 days, linked to Moe's aspiration to study with Kyoka Akira.

Megami-sama's intervention also leads Moe to embrace broader responsibilities: assisting foreign visitors in Akihabara. This expanded duty includes helping otaku purchase figurines while learning basic phrases in English, Korean, Spanish, Chinese, and French. Megami-sama serves as the catalyst initiating Moe's mission.