Poison Sophie, a 20-year-old American with striking blonde hair and piercing blue eyes, operates as an insurance inspector for the Bloody Angels, a ruthless criminal syndicate. Armed with a crossbow and a mastery of toxins, she manipulates targets through poisoned confessions, paralyzing agents, or hallucinogenic compounds. Her vendetta against the United States fuels her ambitions, ignited by the loss of her boyfriend in a U.S.-linked war—a grief that drove her into the Bloody Angels’ ranks to pursue vengeance and dominance.

Tasked with eliminating Lupin III, Sophie first confronts him outside a casino, casually offering a tainted drink. Unfazed due to his precautions, Lupin evades her trap. Undeterred, she escalates her efforts, sabotaging his plane and flooding it with lethal gas. Lupin and his ally, Daisuke Jigen, survive, cornering her in a tense showdown.

As tensions peak, Sophie unveils her tragic past, confessing her despair and urging Lupin to deliver a fatal shot. Before he can act, Emily O’Brien, a fellow Bloody Angel, abruptly ends Sophie’s life with a gunshot. Her story concludes as a testament to her poison-crafted schemes, the emotional turmoil behind her calculated cruelty, and the fatal consequences of her entanglement in the criminal underworld.