George "Stuffy" Cole is a student at Plumfield school run by Jo and Friedrich Bhaer. His nickname "Stuffy" originates from his overweight physique and strong love for food, driving his narrative role. His background before Plumfield remains undetailed. At the school, he lives with other orphaned and non-orphaned children under the Bhaers' care.

Stuffy's appetite and weight form the core of a dedicated episode where teachers and students encourage him toward healthier habits. This storyline involves him struggling with a prescribed diet and increased physical activity; Jo Bhaer contacts his mother regarding the effort. This episode represents his most significant individual moment, though long-term outcomes are not elaborated.

Within Plumfield's group dynamics, Stuffy is generally good-natured. He participates in school activities alongside peers like Tommy Bangs, Nat Blake, and Nan Harding. His relationships with others are not deeply explored beyond his inclusion in the ensemble sharing adventures and lessons. His presence adds diversity to the school's personalities, but he does not drive major plotlines outside his weight-management episode. He appears exclusively in the 1993 anime series.