Anko Daifukuji is a human living in a world where supernatural entities exist. When Komachi, a ghost who perished in the Meiji Era and wandered for over a century, materializes in Anko's room, their encounter sparks a partnership. Together, Anko and Komachi embark on numerous supernatural adventures, frequently crossing paths with other ghosts and demons. These shared experiences drive Anko's central involvement in the series' supernatural events.

Anko serves as a central protagonist alongside Komachi. Other characters associated with Anko include Chiyoko Daifukuji, Monokan Daifukuji, and Tango Daifukuji, suggesting potential familial connections within the narrative.