Dangaizer, an ancient god-like mecha entity, once served as judge, jury, and executioner. Ten millennia ago, its activation reduced human civilization to ashes. Following humanity's rebuilding, the mecha entered dormancy while the malevolent Goma organization awaited its return, intending to harness its power for global conquest.

Activating Dangaizer requires three specific female pilots: Hina Mitsurugi, Cindy Shahani, and Reika Fou. Their synchronization involves wearing revealing neural interface outfits during combat operations against Goma's forces. Dangaizer exhibits ambiguous morality; it functions independently of its pilots' control and displays potentially malevolent intentions, despite being humanity's primary defense.

Opposing Dangaizer is the Goma Corporation, deploying elemental-themed warriors like Sapphire (fire) and Deene (wind), who pilot mechanized Devil Dragons. Dangaizer's physical design presents a distinctive mechanical aesthetic featuring traditional mecha elements, though its full capabilities remain unexplored. The conflict concludes ambiguously after four episodes, with Dangaizer's ultimate purpose and the pilots' fates undetermined.