Nene Midou is the personal maid and housekeeper for Yumiko Kamiazuma, managing the Kamiazuma household. She actively oversees Yumiko's often childish behavior, motivating her to focus on her work as a novelist, going beyond standard domestic duties like cooking and cleaning. Deeply trusted and popular among household members, her sympathetic nature and approachability make her a confidante and stabilizing presence within the family.

Her background holds profound supernatural elements. Nene possesses magical abilities and has lived over 400 years, far exceeding a normal human lifespan. This longevity stems from her lineage as the daughter of the immortal witch Yukihime, from whom she inherited her magic. She has three sisters: Kaya, Anna, and Sarara, the latter identified as an incarnation of Eve.

Nene's relationship with her sister Kaya is complex. Feeling neglected due to Nene's deep commitment to Yumiko, Kaya crafts a substitute named "Nene 108" to combat her loneliness and seek companionship, highlighting the strain caused by Nene's devotion. Nene demonstrates care for Kaya, promising to watch shooting stars together – a promise she fulfills 1,347 years later, sharing the moment with Kaya resting intimately in her lap. She also displayed emotional vulnerability, crying sentimentally when Kaya licked her ear in the kitchen.

Beyond her duties to Yumiko and her bond with Kaya, Nene exhibits nurturing care, such as gently stroking Makoto Inukai's hair bangs while Makoto lay exhausted at the edge of a bath. Her wisdom includes practical knowledge, recognized as an excellent cook and possessing expertise in various medicines.