Nene Kasugano attends junior high school alongside classmates Sunao Moriyama, Mikan Natsu, and Kyō Takamimori. She sports green hair tied with ribbons and distinctive gray eyes that display a gradient or multicolored effect. Her personality is blunt and unrestrained; she voices opinions without hesitation, ignoring social repercussions. She shares close bonds with friends Mikan and Kyō.

Her affluent family resides in a large house featuring amenities like a hot spring expansive enough for her entire class. Three older brothers adore her intensely, though their attentions frequently provoke her to strike them physically. Her mother, appearing remarkably youthful, similarly receives Nene's physical reactions.

A defining dynamic involves classmate Mudō Kirihara. After he mistakenly gifts her Valentine's Day chocolate, she forces him into subservience. He wears a female cheerleader uniform during club activities while obeying her commands. This reinforces her dominant tendencies in social interactions. Observers note her influence in the school hierarchy surpasses even the volatile entity Guchuko, cementing her reputation for assertive control.