Genzo Kuruma, a fanatical scientist and sect leader, obsessively pursues the awakening of a dormant deity through blood rituals requiring a rare hereditary trait. His son, Shinichi Kuruma, and a young girl, Ayaka Sanders, become prime targets due to their unique blood, driving Genzo to hunt them without remorse. He orchestrates unethical experiments, warping genetic codes to engineer "New Humans"—hybrid beings endowed with heightened abilities and monstrous transformations deployed to seize his prey.

Motivated by delusions of divine transcendence, Genzo sacrifices familial bonds, subjecting Shinichi and the boy’s mother to torturous genetic alterations. These acts forge a bitter vendetta, propelling Shinichi to seek retribution. Genzo’s alliances, including a pragmatic pact with strategist Tomisaburou Tengai, serve solely to advance his ambitions, reflecting a calculating mind that weaponizes both science and loyalty.

His existence revolves around ritual completion, disregarding moral boundaries or collateral damage. Ruthless efficiency defines his leadership, merging manipulative charisma with cold scientific precision to command followers and engineered creatures alike in his unyielding quest for apotheosis.