Combeferre is a member of the revolutionary student group Friends of the ABC. He provides a philosophical counterbalance to Enjolras's militant leadership, embodying the movement's intellectual foundations and humanitarian ideals. His design follows the "kuuru megane" anime archetype, featuring glasses and a calm, collected demeanor that conveys intelligence and analytical thinking.

He shares a notably close relationship with Enjolras, marked by mutual respect and frequent collaboration. Their dynamic includes lighthearted moments, like Combeferre inviting Enjolras to sleepovers or suggesting introductions to family members, though these gestures are not necessarily reciprocated. Functioning as a joint leader, Combeferre demonstrates assertiveness in decision-making and strategic discussions. His influence shapes the group's broader ideals of progress beyond immediate revolution.

Within the group, Combeferre readily challenges viewpoints contradicting their revolutionary principles, notably interrupting Marius during Bonapartist rants to reinforce their republican stance. During the barricade sequences, he actively participates in combat while maintaining his philosophical perspective on the revolution's purpose. His death occurs during the final confrontation at the barricade, killed by a cannon blast alongside Joly and Feuilly, contrasting with his novel depiction of dying from bayonet wounds while aiding a wounded soldier.

Combeferre's background includes medical training as a house-surgeon at Necker Hospital, informing his compassionate approach. He advocates for peaceful solutions when possible and delivers a barricade speech urging fathers to consider their survival for their families. His intellectual interests encompass scientific advancement and educational reform, viewing knowledge as essential for societal improvement. He consistently exhibits traits of quiet competence and ideological consistency throughout his narrative arc.