Miss Keane is the homeroom teacher for first-year Class C at Townsville Middle School. Her students include Momoko Akatsutsumi (Blossom), Miyako Gotokuji (Bubbles), Kaoru Matsubara (Buttercup), Himeko Shirogane (Princess Morbucks), and others like Fumika and Hanayo. The school administration, including the principal, deliberately grouped the three heroines together in her class for operational convenience.

She possesses light skin, black hair, and baby blue eyes. Her typical attire features a striped polo shirt with long red sleeves underneath, brown pants, and red sandals. This design differs from her original Western counterpart in its shirt patterns and the absence of a vest.

Generally kind and exceptionally patient, especially with admiring male students, she shows less tolerance toward certain female students, notably disliking Himeko Shirogane (Princess Morbucks). She actively manages the girls' frequent absences. After discussing their habitual class-cutting with faculty, she implemented a strategic plan with countermeasures for every possible excuse they might use to leave. This plan successfully confined them to the classroom until an attack occurred, though she granted legitimate requests like Himeko leaving for her parents' anniversary.

Her interactions extend beyond academics; she confronted Mojo Jojo when he interfered with school activities, delivering remarks that inadvertently insulted him deeply. She is also depicted in a relationship with a boyfriend named Ueno-kun.

Adaptationally, she transitioned from teaching kindergarten in the original Western series to teaching middle school students, reflecting the older age group of the main characters in this version. Her design and role maintain core traits of patience and dedication while adjusting to the anime's setting and character dynamics.