Mayor Mayer governs Tokyo City (called New Townsville in English). He sports gray hair and black eyes, differing from his original counterpart by lacking a top hat and monocle. His standard attire includes a long-sleeved polo shirt with a red bow tie, a green vest, a black jacket, gray slack pants, black leather shoes, and socks.

He exhibits a notably childish personality and short attention span. He frequently voices concern about collateral damage during the Powerpuff Girls Z's battles, urging them to minimize destruction. He possesses a strong fondness for sweets, evident in dessert-themed episodes. He maintains a close working relationship with his secretary, Miss Bellum, heavily relying on her for administrative duties and openly acknowledging this dependence. He also harbors a romantic interest in her, though their relationship remains strictly professional.

He has a younger brother who serves as principal of Momoko, Miyako, and Kaoru's school. Their sibling dynamic is contentious, with minor disagreements often escalating into arguments and name-calling. Despite this friction, he collaborates with his brother on issues like the girls' academics when superhero duties interfere with attendance. He also arranged for the girls to share the same classroom.

His responsibilities involve liaising with Professor Utonium to report threats to Tokyo City and summoning the Powerpuff Girls Z during crises. However, he occasionally diverts them to trivial tasks, such as opening pickle jars.