Makoto Saotome attends Ototachibana Academy as Himeko Kurusugawa's roommate, radiating a cheerful, energetic, and athletic spirit that sharply contrasts Himeko's shyness. Recognized as one of the track team's top runners, her talent positions her to represent the academy in national competitions.

Her appearance features short brownish-orange hair with a single bang pinned by a light green ribbon and striking turquoise eyes. She consistently wears the standard female school uniform. After the academy attack in the series' opening episode, severe head and leg injuries hospitalize her, leaving bandages visible during recovery.

Initially, Makoto pushes Himeko away in the hospital, revealing emotional distress through tearful interactions. Later, she aids Himeko in crucial decisions and supports allies during crises, including assisting Izumi's escape in the Orochi's final assault. By the series' conclusion, she reconciles with Himeko, resuming their shared living arrangement.

Her surname, Saotome (早乙女), merges "early" and "maiden." Himeko exclusively addresses her as "Mako-chan." Born on April 7th, Makoto also informs Himeko about Chikane Himemiya's popularity, particularly detailing the frequent love letters Chikane receives from peers.