Guile manifests within protagonist Haruo Yaguchi's consciousness, embodying his competitive drive and personal growth. This adaptation preserves Guile's established Street Fighter backstory as an American Air Force major seeking vengeance against M. Bison for killing his friend Charlie Nash. His signature moves—Sonic Boom and Flash Kick—alongside core personality traits like dedication to family, country, and justice, remain consistent with the game series.

He serves as Haruo's internal mentor, frequently emerging during moments of self-doubt or critical decisions. Guile's advice often mirrors his own vendetta against Bison, framing Haruo's challenges through fighting game logic. For example, he compares Haruo's romantic pursuit of Akira Ōno to a high-stakes match, urging perseverance and emotional honesty. His guidance evolves alongside Haruo's maturity: initially chastising Haruo for relying on cheap tactics like "Guile turtling," he later acknowledges Haruo's development toward legitimate skill and sportsmanship.

His interactions extend beyond Haruo. During the airport sequence where Haruo races to stop Akira's departure, Guile appears among other game characters representing collective encouragement. He also engages in brief exchanges with Zangief, who fulfills a similar advisory role for Akira, highlighting their contrasting mentoring approaches.

His final narrative role coincides with Haruo's commitment to Akira. After Haruo confesses his determination to marry her despite her move abroad, Guile's manifestations cease, implying his purpose as a motivational force is fulfilled.