Nene Nanakorobi is a full-conversion cyborg, her entire mechanical body housing her organic brain. This transformation was necessitated by Pyxis Syndrome, an incurable illness detailed in the manga, to save her life. Shaped by the traumatic loss of her parents in a house fire, she developed a strong commitment to helping others. Seeking a new beginning, she relocated to Cenancle Island to live with her aunt, Takumi Korobase.

Her personality radiates naive optimism and high energy, coupled with an unwavering dedication to achieving world peace. Despite her innocent demeanor, she demonstrates intelligence and adaptability, frequently leveraging her cyborg capabilities in unexpected ways. She forms an instant, deep bond with the combat android Clarion, often expressing affection through hugs and physical closeness. This relationship deepens through shared experiences, with Nene displaying fierce protectiveness over Clarion, especially when others threaten her.

Nene's primary ability involves interfacing directly with the Pandora Device within Clarion’s body. By inserting her fingers into Clarion’s abdominal port, she temporarily gains mastery of specialized skills, from combat techniques to culinary arts. Beyond this, her cyborg body exhibits unexpected capabilities, such as unconsciously accessing remote systems or performing complex tasks without direct input—termed "Achievements in Ignorance." She also possesses the capability to transfer her brain between different artificial bodies.

Her development charts an evolution from a sheltered individual into an active protector. Early interventions, like stopping terrorist attacks or rescuing civilians from disasters, solidify her resolve to pursue world peace through direct action. She confronts threats like the rogue excavation robot B.U.E.R., volunteering for high-risk missions, including one where she nearly sacrifices herself to neutralize its laser. Her idealism matures into pragmatic determination, exemplified by her declaration to leverage financial resources to "buy" peace.

Her dynamic with Clarion evolves into profound mutual dependence and loyalty, with both frequently rescuing each other from peril. Nene’s interactions with other characters, such as her socially anxious aunt Takumi or the inventor Uzal Delilah, further showcase her adaptability and persistent optimism in complex situations. Physically, she has aubergine hair, red eyes, and visible mechanical joints, occasionally leading others to mistake her for an android. Her design sometimes incorporates Elegant Gothic Lolita aesthetics during specialized functions like optical camouflage.