Alice Liddell grapples with insecurity and feelings of inferiority, especially compared to her older sister Lorina, whom she views as more beautiful and graceful. This self-doubt originates in her past, including a painful romantic relationship where her ex-boyfriend abandoned her for Lorina, fostering her distrust of love and emotional vulnerability.

Peter White, a rabbit-eared humanoid, forcibly transports her to Wonderland after she dismisses his initial appearance as a dream. He compels her, via a kiss, to drink a potion binding her to a "game." To refill the vial and potentially return home, she must engage socially with Wonderland's inhabitants, forcing her interaction despite the world's dangers.

Initially dismissing Wonderland as a dream, Alice adopts a blunt, sarcastic, and pragmatic attitude, frequently challenging the residents' violent or illogical behaviors. Her realism and value for life starkly contrast with Wonderland's inhabitants, entrenched in perpetual civil war and casual disregard for mortality. This contrast becomes a core reason for their collective fascination and romantic interest in her, though her innate sincerity often leads them on unintentionally.

Recurring headaches, induced by the dream demon Nightmare Gottschalk, plague Alice when she tries to recall memories of her sisters Lorina and Edith. These episodes deter her from fixating on returning home and contribute to her gradual emotional investment in Wonderland. Her primary residence is the neutral Clock Tower, where she lives with Julius Monrey, the realm's clockmaker and de facto mortician. Julius repairs the clocks that function as the residents' hearts, enabling their revival after death—though often with altered personalities. Alice assists him, forming a close, platonic bond and describing him as outwardly cold yet fundamentally kind. Their shared pragmatism and mutual support create a stable foundation for her in the chaotic world.

Her relationships are complex: Boris Airay (Cheshire Cat) is a close companion; she scolds his recklessness but tends to his wounds, reflecting her caring nature, and maintains friendship despite his romantic advances, often reacting with physical rebuffs. Her dynamic with Blood Dupre (Mad Hatter) begins civilly but sours due to his jealousy, leading him to spread rumors. His resemblance to her ex-boyfriend causes discomfort, evolving into a contentious love-hate connection. In later media, she acknowledges romantic feelings, leading to marriage. Vivaldi (Queen of Hearts) views Alice as a sisterly figure, mirroring her bond with Lorina; mutual trust allows Vivaldi to reveal her secret affection for stuffed animals, strengthening their friendship. Alice finds Peter White's obsessive stalking and declarations of love irritating, often responding with physical rejection, yet she uniquely influences him to spare lives due to her reverence for existence.

Her development centers on overcoming isolation and self-doubt. Through interactions with Wonderland's residents—including the protective Tweedle twins, the enigmatic Ace, and the ailing Nightmare—she forms genuine connections and re-evaluates her desire to return home. Revelations across media ("Truth End") clarify Wonderland's mechanics, particularly the clocks' significance and revival process. This knowledge, combined with her forged bonds and lingering Earthly traumas, culminates in her voluntary decision to remain in Wonderland, accepting it as her new home.