Prince Shōtoku features as a fictional character in the anime "Gag Manga Biyori," specifically in Episodes 2 and 3 of Season 1. He undertakes a historic mission as an imperial consul (Kenzuishi) to China, traveling by ship to Luoyang with his companion Ono no Imoko to deliver a sovereign letter from the Emperor of Japan to Emperor Yang of Sui. During the arduous voyage, both Prince Shōtoku and Ono no Imoko suffer from "long-term travel insanity," a severe psychological distress causing erratic behavior and mental instability. Upon arrival in Luoyang, they proceed to the imperial court to present the letter. The narrative takes an absurdist turn when Emperor Yang is revealed to secretly be an extraterrestrial from the planet Octopus, masquerading as human and manipulating human minds. The encounter descends into chaos, resulting in disastrous and farcical outcomes during the diplomatic exchange. The letter delivery culminates in unintended consequences as "things go quickly and horribly wrong," driven by the emperor's alien nature and the envoys' compromised mental states.