Megumi Sakura advised the School Life Club at Megurigaoka Private High School. Though she preferred "Sakura-sensei," students affectionately called her "Megu-nee." Her duties extended beyond conventional teaching, intensely focused on her students' emotional and physical safety. When a catastrophic infection outbreak occurred, her protective instincts persisted even after she became infected. Demonstrating extraordinary willpower, she retreated to the school basement to avoid harming the girls she cared for. This act highlighted her profound commitment, evidenced by journal entries preserving her students' names and detailing her struggle against her deteriorating condition.

Her influence endured beyond her physical presence, guiding the School Living Club members through subsequent challenges. The infection granted her enhanced physical capabilities, including sharp claws and heightened senses. Yet, she prioritized suppressing her violent impulses to safeguard her students. Her resistance to the infection's typical behaviors underscored her lasting sense of responsibility and emotional resilience.

In her transformed state, she retained advanced combat skills and strategic intelligence. She proved capable of summoning other infected entities and weakening adversaries through supernatural means. Her tactical acumen remained evident in engagements as she leveraged these new abilities while consciously suppressing her hunger around those she protected. This duality exemplified her unwavering dedication as an educator, her actions continuing to shape the students' survival and morale long after conventional teaching became impossible.