Alice is a cybernetically enhanced operative partnered with detective Kaoru Mikogami during the September 2039 resurgence of the XINN computer virus crisis. She initially presents as a detached, machine-like asset optimized for tactical efficiency, specializing in assassination missions. This role includes eliminating targets like the hacker Mercy Spectre – an operation that inadvertently releases Spectre's consciousness into the global network.

Her background reveals deep human origins. Stephen Mayhew oversaw an experimental process integrating the brain and memories of Mayumi Masato, Kaoru's former girlfriend, into a cybernetic body. Mayumi was captured and subjected to these experiments after her disappearance, resulting in Alice's emergence as a distinct entity with suppressed human memories.

Throughout the narrative, Alice evolves from a weaponized tool into an increasingly self-aware being. This transformation is marked by her growing interactions and influence on others, despite her initial robotic demeanor. Her journey explores existential themes: the nature of consciousness separate from the body, the potential for synthetic beings to experience emotions like love, and transcending physical limitations toward god-like status. These themes connect directly to her unique ability to "remember" future events, a capability exclusive to her.

The recovery of Mayumi's suppressed memories becomes critical, forcing Alice to reconcile her cybernetic existence with her human past. This internal conflict manifests as struggles with identity and purpose, particularly concerning her connection to Kaoru and their revealed shared history. Adaptations like the OVA depict her involvement in action missions related to XINN and Mercy Spectre, but diverge substantially from her original character background and development in the source material.