Sherlock Holmes manifests as an anthropomorphic dog reflecting his literary persona: a genius intellect with vast multidisciplinary knowledge and unwavering logical methodology. His residence remains perpetually cluttered and often saturated with chemical experiment fumes. His sole substance habit is pipe smoking, differing from traditional depictions, and he employs a Benz Velo automobile for investigations.

Holmes confronts elaborate criminal schemes orchestrated by Professor Moriarty, who personally executes plans featuring steampunk technology. Key cases involve recovering the stolen Blue Carbuncle gem and thwarting a Royal Navy submarine theft. During the Blue Carbuncle investigation, Holmes simultaneously reforms a young pickpocket toward lawful conduct.

His landlady, Mrs. Hudson, diverges from conventional portrayals as the young widow Marie. She exhibits expert driving, sharpshooting, and aviation connections via her late pilot husband. Her composure and resourcefulness rival Holmes’s capabilities, and she actively assists in cases while attracting romantic interest from Holmes and others.

Moriarty invents the steampunk technology central to their conflicts and engages Holmes in frequent direct confrontations, unlike his literary counterpart’s background role. Two anthropomorphic henchmen, Smiley and Todd, assist Moriarty with comedic interplay—Smiley’s optimistic simplicity contrasts Todd’s constant plan-criticism.

Holmes collaborates with Inspector Lestrade of Scotland Yard, who requests investigative aid despite an impulsive nature. Lestrade’s unit routinely fails to apprehend Moriarty, generating slapstick-style comedic scenarios.