Sherlock Holmes, a consulting detective based at 221B Baker Street in London, once famed for solving high-profile cases, withdrew from prominence following a clash with Lupin III that resulted in the death of his ally, John Watson. Retired and disenchanted, he now handles trivial inquiries—tracking lost pets or unraveling marital disputes—while serving as guardian to Watson’s daughter, Lily, who resides with him.

His appearance shifts subtly over time: initially unkempt with a beard and scruffy hair, he later adopts a cleaner look, retaining only a faint mustache. He dresses in a dark gray jacket and light gray trousers, maintaining a subdued yet functional style. Watson’s demise during a clash with the covert group known as the Raven fuels Holmes’s lingering bitterness toward Lupin, whom he initially holds responsible. The tragedy left Lily with fragmented memories and chronic headaches, compelling Holmes to guard her from further distress.

Lupin’s return to London reignites Holmes’s investigative fervor, driven by Lupin’s pledge to avoid Lily. To probe the Raven’s secrets and assess Lupin’s motives, Holmes adopts calculated disguises, including mimicking Inspector Zenigata. His approach blends sharp deduction with combat prowess, enabling him to challenge foes such as Goemon Ishikawa XIII.

The Raven case intertwines with Colonel Sebastian Moran, an assassin tied to Professor Moriarty, unveiling deeper conspiracies. Holmes navigates a dual mission: pursuing justice for Watson’s death and shielding Lily, whose trauma resurfaces through haunting recollections of her father’s final moments.

Ambiguities linger around Holmes’s lineage within the Lupin III universe, including potential ties to an earlier figure named Sherlock Holmes III. While legal disputes historically prompted alternate pseudonyms like “Herlock Sholmes” in other adaptations, this iteration retains the original name without deviation.