George Lestrade is an inspector for Scotland Yard in the anime Moriarty the Patriot. He is depicted as a man with brown hair and dark blue eyes, consistently dressed in the professional attire of his era, which includes a suit, a blue tie, a white shirt, and a hat. His role within the story is that of a dedicated police officer who frequently serves as a direct point of contact and collaborator with the private consulting detective, Sherlock Holmes.

In terms of personality, Lestrade is defined by a strong moral compass and a sincere commitment to his duty of protecting the public and solving criminal cases. He deeply values his role and is frequently frustrated by corruption and negligence within his own institution. This is particularly evident in his conflicts with his superior, Inspector Arterton, whose dismissive attitude toward justice, such as in the case of the Whitechapel murders, Lestrade finds reprehensible. He is a courageous individual, unafraid to jeopardize his own career when he believes an innocent person is at stake, as seen when he physically confronts Arterton to access confidential files or commandeers a police boat to pursue a suspect.

A key aspect of his character is his relationship with Sherlock Holmes. Lestrade recognizes Sherlock's unparalleled deductive abilities and, despite finding his personality difficult and stubborn, sees him as a last resort when the police investigation reaches a dead end. His trust in Sherlock is profound; even when the detective is the primary suspect in a murder, Lestrade doubts his guilt and ultimately aids his escape so that the real culprit can be found. This trust places Lestrade in the position of being perhaps the Scotland Yard inspector closest to Holmes. His interactions are not limited to Holmes, as he also observes the intellectual prowess of William James Moriarty, at one point remarking that dealing with both men feels like managing two Sherlocks.

Lestrade's motivations extend beyond simply closing cases. He is driven by a dislike of injustice and a refusal to let the wrong person be punished. During the rebellion at Scotland Yard, he is determined to expose a conspiracy that has led to an innocent man being framed for the Jack the Ripper murders. He actively works to uncover falsified budget records and prove the scheme, even at great personal risk. This arc highlights his development from a dependable, if conventional, inspector into an officer willing to challenge systemic corruption from within.

Notable abilities include his investigative competence and his courage in taking direct action. While he may not possess the genius-level intellect of Holmes or Moriarty, he is a capable policeman with experience in gathering evidence and conducting inquiries, such as when he travels to Wales to investigate a victim's background. His true strength lies in his unwavering integrity, his willingness to learn from and trust those more brilliant than himself, and his readiness to act on his convictions to see justice served.