TV-Series
Description
Kyosuke Irie directs the Irie Clinic in Hinamizawa and coaches the village's baseball team, the Hinamizawa Fighters. Born into poverty, he aspired to become a doctor from a young age. His father, a construction worker, developed violent outbursts due to an organic brain syndrome from a head injury, leading Irie's mother to flee. After his father died in a street fight, Irie pursued neurosurgery, specializing in psychosurgery to help others with similar conditions.

Irie gained recognition for successful lobotomies during his medical career but continued performing them illegally after the practice was banned, believing them necessary to treat mental illness. This resulted in his expulsion from the medical community. His controversial research attracted "Tokyo," a secret organization that recruited him into Takano Miyo's research group on Hinamizawa Syndrome. The Irie Clinic was established as a front for this research, with Irie as its nominal head to appease "Tokyo's" leadership, though Takano held de facto control.

Deeply involved in suppressing Hinamizawa Syndrome, Irie developed an experimental treatment for Satoko Hōjō, administering regular injections to prevent her symptoms from progressing. When her brother Satoshi reached the terminal stage of the syndrome in 1982 after murdering their abusive aunt, Irie placed him in a pharmacological coma within the clinic's hidden research facility. He concealed Satoshi's condition for years, only revealing it to Shion Sonozaki in *Matsuribayashi-hen*. His relationship with Satoko includes inappropriate jokes about maid outfits and marriage, though he genuinely cares for her well-being.

Throughout multiple story arcs, Irie serves as an unwitting pawn in Takano's plans. He complies with unethical actions, such as vivisecting a terminal Syndrome patient, to advance research but resists harming children. In timelines where Takano instigates the Great Hinamizawa Disaster, Irie accepts his role as a scapegoat and commits suicide via sleeping pills overdose before authorities can arrest him. However, in *Matsuribayashi-hen*, Rika convinces him of Takano's true intentions, leading him to oppose her.

An early concept envisioned Irie as a ruthless antagonist revealing Satoshi's preserved brain to Satoko, but this idea was abandoned after criticism, with Takano replacing him as the primary antagonist. In *Higurashi no Naku Koro ni Rei*, set 35 years after the original events, Irie remains active in the village.