Shizuka Minamoto participates alongside Nobita, Gian, and Suneo in a musical adventure. They practice recorders by the riverbank, encountering the mysterious girl Mikka, leading to an impromptu concert using toys enhanced by "Robotters" and the "Mood-boosting Orchestra."

The group later receives a mysterious invitation to their school's music room at night, transporting them to the "Fare Hall of Fame." There, Mikka and her robot companion Chapek recruit them as potential "virtuosos" to revive the dormant hall using musical energy called "Fare." Shizuka obtains a "musician's license" and partners with bongo drums via Doraemon's "Red Thread of Fate" gadget. She contributes to revitalizing locations like the dried "Harp River" and the "Otomushi Forest."

During the climax, Shizuka recalls a music class lesson about the world's oldest musical instrument—a swan bone flute displayed in Tokyo's Ueno Museum. This memory proves crucial for locating an artifact tied to Mikka's heritage and combating the Noise entities threatening Earth.

When discord erupts during an attempt to heal a noise-infected Doraemon through music, causing arguments between Gian, Suneo, and Nobita, Shizuka steps in to mediate. Her intervention restores group cohesion, enabling their subsequent performance combined with Mikka's singing to expel the noise spores from Doraemon.

Shizuka joins the final "Earth Symphony" performance with Nobita, Gian, Suneo, Mikka, Vento, and the musician robots. This collective effort, amplified by accidental spacetime manipulation from one of Doraemon's gadgets, repels the Noise entity in space.