Natsuki Enra works as a nurse in Y Academy's infirmary and acts as second-in-command to Kinya Daiouji in the Yo-kai Special Power organization. She scouts students with YSP potential, providing Jinpei Jiba a YSP Watch after witnessing his abilities against Wampus. This device unlocks transformations into Yo-kai Heroes like Kengo Benimaru. She guides Jinpei via earpiece during missions and facilitates the YSP Club's formation with Jinpei, Sandayu Koma, Mera Raido, Mataro Tamada, and Fubuki Himekawa.

Her slender frame features dark blue eyes highlighted by aquamarine eyeshadow and lashes, light cyan hair often obscuring her right eye, and pink lipstick. She dons a loose white lab coat over a dark-blue sleeveless turtleneck sweater, paired with a yellow pencil skirt, teal high heels, yellow earrings, and cyan nail polish. She blends an alluring presence with sincere care for students and mission success, specializing in spiritual entities like Yo-kai and Onryo. Yoga maintains her physique.

She first observes Jinpei and Sandayu confronting O-Eater, reporting their skills to Kinya Daiouji to secure their Y Academy enrollment. Her influence proves pivotal when Ryusuke Kyubi loses focus during a fight with Jinpei upon seeing her, resulting in his defeat and later recruitment. Indirectly, she triggers the "Forbidden Love Curse" incident after Ryusuke transforms into Hebimaju upon glimpsing her yoga practice. A shapeshifting Onryo later mimics her form, morphing into Medusa to assault the YSP Club before defeat.

Her background identifies her as Smogmella's reincarnation. She favors Café au Lait imbued with floral notes.