Enzo Bron was born in Lyons to geographer Alan Bron and Italian screenwriter-actress Renata Ricorellino. After graduating from École Polytechnique, he relocated to America for a Stanford University research position, where he founded the IT conglomerate Shake Hanz Corporation. He married Japanese translator Yuko Enan, and they had a daughter, Ami. The marriage dissolved within three years, followed by Yuko's suicide. Enzo remained minimally involved in Ami's upbringing, fostering distance.

As Shake Hanz CEO, Enzo created and championed "PeopleLog," a social media application employing artificial intelligence for behavior prediction, facial recognition, and disguised individual identification. The app assigned compatibility scores to interactions. Enzo deemed PeopleLog infallible and exploited it to manipulate others, including luring Lupin III to test its capabilities. He orchestrated Fujiko Mine's kidnapping, confining her in a golden cage, and deceived Goemon Ishikawa XIII into battling Lupin by falsely claiming Goemon was merely a collectible in Lupin's possession.

Enzo's actions drew scrutiny from global mercenaries, the United Nations, and law enforcement, including Inspector Zenigata. During the collapse of Shake Hanz's Orig Island headquarters, Enzo escaped alongside Ami. This shared survival forged a genuine bond, a stark shift from his prior neglect. His protective stance solidified after Ami publicly revealed their relationship during a confrontation.

Later, Enzo collaborated with corrupt French official Albert d'Andrésy, leveraging Shake Hanz's cyber-trafficking operations for wider influence. Albert ultimately betrayed Enzo, designating Shake Hanz a terrorist organization and precipitating its downfall. Enzo's development centered on reconciling his technological ambitions with his rediscovered paternal connection, moving from viewing relationships through data metrics to authentic human engagement.