Isaac Wisemel operates as a high-ranking executive within Inferno, the powerful criminal syndicate functioning as a "United Nations of crime syndicates." He serves directly as the right-hand man to Raymond McGwire, one of Inferno's foremost leaders, and commands the Bloodies, Los Angeles's strongest street gang. This dual role places Wisemel among the three highest-ranking members of the Inferno hierarchy.

A bitter, ongoing feud exists between Wisemel and fellow executive Claudia McCunnen, stemming directly from his involvement in the death of her brother, an act linked to his Bloodies. This history fuels their persistent hostility, making agreement rare. Wisemel possesses a volatile temperament, easily provoked by minor issues and nursing deep resentment against numerous figures within Inferno. He exhibits particular disdain for newcomers, treating Zwei with condescension and actively pursuing the younger operative's elimination from the organization.

During the OVA's events, Wisemel engages directly in field operations. He confronts Zwei in a tactical sniper duel, strategically using the urban environment for cover and positioning, revealing the coordinated presence of multiple assassins. His role consistently involves manipulation and wielding authority from within Inferno's structure.