Nene Sakurada is a five-year-old classmate and friend of Shinnosuke Nohara in the Sunflower Class. She maintains a polite and sweet demeanor but harbors a strong, bossy temperament inherited from her mother. Her signature activity involves coercing classmates like Masao Sato, Toru Kazama, and Shinnosuke into playing "real omamagoto," where she consistently takes the mother role. These games often escalate into domestic conflicts such as arguments and divorces, making the boys reluctant participants. Masao Sato typically becomes her unsuccessful salaryman husband, bearing the brunt of her frustrations. When angered—a frequent occurrence—she relieves stress by hitting a stuffed bunny toy, mirroring her mother's habit; Masao serves as her substitute outlet when the toy is unavailable.
She views Ai Suotome as a rival and reacts with jealousy when male classmates favor Ai over her. Her interests include caring for multiple pet cats and watching the television show "Magical Girl Moe-P." As a member of the Kasukabe Defense Organization, she joins group activities with Shinnosuke, Masao, Kazama, and Bo Suzuki.
Her closest bonds are with Shinnosuke and Masao. She frequently partners with Masao during group separations and dominates him in games. Though often impatient with Shinnosuke's antics, she shows care by inviting him on outings with her mother and expressing distress over potential separations like his planned move to Mexico. She exhibits possessiveness, clashing with others over Shinnosuke's attention. Kazama tolerates her house-playing games despite disliking them, and she displays jealousy when other girls engage with him. Her friendship with Bo Suzuki reflects mutual understanding and support.
Her family life includes a father who shares her habit of exclaiming "you're not my usual wife!" when her mother acts out of character, reinforcing Nene's own reactions to her mother's behavior. She is listed in the cast of "Unkokusai's Ambition."