Genzō Makishima commanded the Japanese branch of the Chronos Corporation as director and foster father to his biological nephew, Agito Makishima. He seized leadership by usurping Max Pharmaceuticals from his brother, whom he murdered to adopt Agito, enabling Chronos to absorb the company. His ruthless ambition and breakthroughs in advanced Zoanoid models secured his position. Repeated failures to reclaim three stolen Guyver units led to his demotion. Punished by Chronos official Richard Guyot, Genzō underwent forced transformation into Enzyme I—a prototype Zoanoid engineered to eliminate Guyver units. The flawed process granted immense strength, corrosive blood, and armor-dissolving enzymes channeled through claws, teeth, and a tail stinger, but shortened his lifespan to seven days. Consumed by vengeance, Genzō battled Guyver I, tearing out its control medal to trigger a fatal armor overload. Despite this triumph, Guyot remotely detonated Enzyme I, erasing both combatants. His destruction emphasized Chronos’s cold pragmatism in discarding even elite assets. Genzō wielded pride and manipulation with callous precision, exploiting others for personal gain. He scapegoated subordinates, evaded accountability, and cowered before superiors like Guyot. His relationship with Agito remained transactional, stripped of familial ties, though rare loyalty surfaced toward subordinate Synevite in select adaptations. Across OVAs and the 2005 anime, Genzō persisted as a cunning antagonist whose hubris catalyzed his transformation and demise. His Enzyme I design fluctuated slightly between iterations but maintained core traits: white fur, a hulking frame, and biomechanical armaments tailored for melee combat. The unstable Zoanoid form’s fatal flaws underscored Chronos’s merciless efficiency in purging liabilities.