Maria Tengai emerges as a figure central to religious symbolism, her existence entwined with efforts to resurrect a divine entity. Identified as the reincarnation of the Virgin Mary, she becomes a target of the clandestine organization “13 Doctors” or “Apostles,” who seek to exploit her sacred lineage to revive their deity. Her life culminates during the “Great Destruction”—a cataclysmic chain of earthquakes tied to her death—which devastates Shinjuku and leaves her remains fused with Shinichi Kuruma’s body, binding their fates irrevocably.

Her blood, a vital catalyst for completing the resurrection of “God,” fuels relentless pursuit by adversaries, including those hunting Ayaka Sanders, whose survival hinges on Shinichi’s cells and forges a psychic tether between them. Though her physical form perishes, Maria’s spirit persists, merging with other characters to influence Shinichi’s choices and emotional journey. Her legacy weaves through themes of sacrifice and cycles of conflict, positioning her as the spark for historical and ongoing turmoil, her presence echoing through both memory and the living threads of those she touched.