Sakurako Ōmuro is a first-year student at Nanamori Middle School and a member of the Student Council. She has wavy blonde hair, brown eyes, and average height, typically wearing red and black hair clips on the left side of her head. Her physical appearance includes a notably small bust, a recurring point of self-consciousness and teasing, especially compared to her childhood friend Himawari Furutani.

Personality-wise, Sakurako exhibits laziness and unreliability, frequently neglecting responsibilities like homework, which Himawari often completes. She possesses a short-term memory, forgetting instructions or information almost immediately. Despite this, she displays athleticism and takes pride in teasing Himawari about her lack of athletic prowess. Sakurako is gullible, easily believing most things she hears, and shows gluttonous tendencies, preferring pre-prepared meals over cooking. Academically, she struggles with frequent kanji writing errors, resulting in unintended meanings. While sharing similarities with Kyōko Toshinō in exuberance, Sakurako performs poorly academically and demonstrates greater laziness.

Her background involves a long-standing, complex relationship with Himawari. They were close childhood friends, even participating in a mock wedding orchestrated by Sakurako's older sister, Nadeshiko. Over time, their dynamic evolved into a rivalry marked by regular arguments, often over physical differences. Despite this, Sakurako retains underlying affection for Himawari, evident in her secret happiness when receiving homemade biscuits or lending Himawari her gym shirt. Their interactions often include physical clashes and mutual insults, yet they spend significant time together, including meetings during free periods.

Sakurako's family life is explored in the spin-off *Ōmuro-ke*, detailing her relationships with her sisters. Nadeshiko frequently scolds her for laziness and poor common sense. Hanako, her younger sister, often quarrels with her over minor issues like consumed food but demonstrates care, such as making pancakes for Sakurako after she felt excluded. Sakurako reciprocates this care, preparing porridge for Hanako during illness and winning her desired pajamas, revealing mutual affection beneath their bickering.

Her Student Council role stems from Himawari’s decision to join; Sakurako disliked the idea of Himawari participating without her. Though not academically inclined, she genuinely desires to contribute to improving school life, expressing admiration for selfless individuals like Akari Akaza. Her competitive streak emerges in attempts to prove herself more suitable for the vice presidency than Himawari, despite lacking academic diligence.

Sakurako interacts beyond Himawari. She bonds with Kyōko over their similar personalities, visits Chinatsu Yoshikawa’s house (playing with her hair without objection), and shares a friendly dynamic with Akari, united as targets of club-related teasing. She once hugged Ayano Sugiura from behind while declaring "I Love You!" and exchanged dinner feeding with Himawari, highlighting her physically expressive and impulsive nature.

In the OVA *YuruYuri Nachuyachumi!+*, Sakurako’s forced "date" with Himawari during a New Year’s drawing event shows their tsundere dynamic: initial bickering transitions to feeding each other. The *Ōmuro-ke* films further develop her family relationships, emphasizing occasional sincerity amid typical sibling conflicts.

She fears cockroaches (unlike Himawari, who fears snakes) and enjoys Isobe fries. Her name combines "cherry blossom" (櫻/sakura) and "child" (子/ko), with her surname Ōmuro meaning "big" (大) and "room" (室).