Nene Onemine attends Itan Private High School, transitioning from first-year class 1 to third-year class 4. She sports brown hair styled in a ponytail, a skirt worn above the knees, an untucked shirt, and barely visible socks during activities. Two moles mark her face—one beneath her left eye and another near her lower lip’s right side. The eldest of five siblings, she oversees her brothers Takeru and Kazuya and sisters Nono and Nana in their family’s modest single-story home. Her caretaking extends to managing eight cousins during a summer reunion, showcasing her organizational aptitude. Observant and nurturing, she subtly supports classmates, notably recognizing Komi Shouko and Hitohito Tadano’s mutual affection. She engineers scenarios for them to connect, such as pairing them during cultural festival errands. At the festival, she shops with Komi and Otori Kaede, bonds over rice ball preparation, and joins group celebrations. She detects Komi’s unease at a cat café, gently urging her to engage with the animals. Her perceptiveness aids peers during school trips and events, like defusing tension in Kyoto’s communal baths or participating in a Christmas King Game. As class representative, she assists Tadano with student council tasks and performs in the cultural festival dance. She becomes Komi’s 13th friend by signing her "friend register" and later observes Manbagi Rumiko’s love triangle discreetly. Nicknamed "Bibi Combo" with Otori Kaede due to shared surname characters, she frequently clasps Otori’s hand to prevent her wandering—a habit stemming from Otori’s tendency to vanish. Born July 7 under the Cancer sign, she ranks third in character popularity polls. Her name incorporates a Japanese pun on "communication disorder," aligning with the series’ themes. She stands approximately 165 cm tall, weighs around 44 kg, with slight variations across sources.