Misaki is an elderly figure associated with the research center that held the Kirihara brothers. He is a highly powerful psychic, though the full extent of his abilities is never specified. Among his most significant feats is the creation of a mystical barrier around the research center, a barrier that was sensitive to individuals and selectively kept certain people out while confining others within its limits. This barrier remained in place until his death, which occurs at the very beginning of the series; its collapse allows the brothers to escape and sets the main story in motion.

Misaki possessed the power of foresight, enabling him to perceive future events. He is regarded with great respect by key characters, including Kyojiro Mikuriya, the Kirihara brothers Naoto and Naoya, and Shouko Futami. His motivations are not directly explored, but his actions—particularly the construction of the barrier and his apparent foreknowledge—suggest a protective or guiding purpose related to the impending upheaval. His personality is portrayed as mysterious and withdrawn; he remains a presence at the research center whose influence and importance are acknowledged by those who knew him. Because he dies early in the narrative, his character does not undergo development, but his legacy and the fallout of his death drive the plot forward. He appears in both the 2006 anime adaptation Night Head Genesis and the 2021 series Night Head 2041, maintaining the same fundamental role across versions.