"Kuso Miso Technique" is a comedic manga that revolves around the absurd and chaotic life of its protagonist, Miso Suzuki, a high school student with an unusual talent for creating bizarre and often grotesque inventions. These inventions, referred to as "techniques," are typically nonsensical and serve as the primary source of humor throughout the series. Miso's creations frequently disrupt the lives of those around her, including her classmates, teachers, and even strangers, leading to a series of escalating comedic situations.

The narrative is episodic, with each chapter focusing on a new invention or scenario. Miso's best friend, Mayu, often becomes an unwilling participant in her schemes, providing a grounded contrast to Miso's eccentric behavior. The dynamic between the two characters is central to the story, with Mayu frequently exasperated by Miso's antics but ultimately remaining loyal. Other recurring characters include Miso's classmates and teachers, who are often drawn into the chaos caused by her inventions, adding to the series' comedic tone.

The humor in "Kuso Miso Technique" is heavily reliant on slapstick and absurdity, with Miso's inventions often defying logic and physics. The series does not aim for realism, instead embracing its over-the-top premise to deliver consistent comedic moments. Despite the lack of a continuous overarching plot, the episodic nature of the manga allows for a variety of humorous scenarios, ensuring that each chapter offers something new.

Themes of friendship, creativity, and the consequences of unchecked imagination are subtly woven into the narrative, though they are secondary to the primary focus on comedy. The series maintains a lighthearted tone throughout, with no significant dramatic or serious moments. "Kuso Miso Technique" is characterized by its fast-paced, gag-driven storytelling, making it a straightforward and entertaining read for fans of absurd humor.