"Meika-san wa Oshi Korosenai" centers on Meika Hoshizaki, a high school student who is the daughter of a wealthy and influential family. Despite her privileged background, Meika is determined to live a normal life and rejects the luxuries afforded by her family. She attends a public high school and works part-time at a convenience store to support herself, striving to be self-reliant and independent. Her strong-willed nature and refusal to rely on her family's wealth make her a unique and compelling protagonist.

The story introduces Akira Shirogane, a classmate who becomes intrigued by Meika's determination and begins to develop feelings for her. Akira is initially unaware of Meika's wealthy background, and their interactions are marked by a blend of humor, misunderstandings, and growing affection. As their relationship develops, Meika's efforts to maintain her independence are challenged by her family's expectations and the societal pressures tied to her status. The narrative explores themes of identity, self-reliance, and the complexities of balancing personal aspirations with external expectations.

Supporting characters include Meika's family members, who represent the opulent lifestyle she rejects, and her coworkers and classmates, who provide a contrast to her privileged upbringing. The series balances comedic moments with heartfelt scenes, creating a dynamic portrayal of Meika's journey as she navigates her dual identity. The plot progresses through a series of episodic encounters and conflicts, highlighting Meika's resilience and her evolving relationships with those around her. The manga's focus on character development and interpersonal dynamics makes it a engaging exploration of personal growth and societal norms.