Tadayasu Sawaki, now a second-year student at a certain agricultural university, carries on his family's trade as the son of a tane koji shop owner. He possesses an extraordinary ability: he can see and communicate with microorganisms and bacteria with the naked eye, perceiving them as distinct, personified creatures. Alongside his childhood friend Kei Yuuki, whose family runs a sake brewery, and the eccentric members of Professor Itsuki's fermentation seminar, Tadayasu navigates the chaotic and often absurd campus life of Nodai University. The story picks up in the modern Reiwa era, beginning with the university's traditional Spring Festival, a time of brewing, experimentation, and microbial mayhem. Whether dealing with sake fermentation mishaps, rivalries between beneficial and harmful bacteria, or the everyday troubles of agricultural college students, Tadayasu's unique gift continues to involve him in the hidden world of microbes. The series continues to blend comedy, educational insights into fermentation and microbiology, and the warm, messy camaraderie of its cast, all set against the backdrop of a university where the smallest organisms often cause the biggest commotions.