"Genshiken" is a manga series that explores the lives of college students involved in a university club dedicated to otaku culture, particularly anime, manga, and video games. The story centers around the members of the Genshiken (short for "Gendai Shikaku Bunka Kenkyūkai" or "The Society for the Study of Modern Visual Culture"), a club that serves as a gathering place for individuals with shared interests in niche hobbies. The narrative begins with Kanji Sasahara, a freshman who initially feels hesitant about embracing his otaku identity but eventually joins the club after being drawn to its welcoming atmosphere. Through Sasahara's perspective, the series delves into the dynamics of the club and its members, showcasing their interactions, hobbies, and personal growth.

The club's members include a diverse cast of characters, each with distinct personalities and interests. Makoto Kousaka, a confident and skilled otaku, is known for his expertise in gaming and his relationship with Saki Kasukabe, a non-otaku who struggles to understand the club's culture but becomes an integral part of their lives. Other notable members include Harunobu Madarame, a passionate and outspoken figure who often serves as the club's de facto leader, and Mitsunori Kugayama, a quiet and artistic member who contributes to the club's creative projects. The group also includes female members like Ohno, a cosplayer with a deep love for anime, and Ogiue, a talented but initially reluctant manga artist who grapples with her feelings about otaku culture.

The narrative progresses through episodic arcs that highlight the club's activities, such as attending conventions, creating doujinshi (self-published works), and navigating the challenges of balancing their hobbies with academic and social responsibilities. The series also explores the relationships between the characters, including romantic tensions, friendships, and conflicts, providing a nuanced portrayal of their lives. Over time, the story shifts focus to new generations of club members as the original group graduates, ensuring continuity while introducing fresh perspectives and dynamics.

"Genshiken" is notable for its realistic depiction of otaku culture, avoiding exaggerated stereotypes in favor of a grounded and relatable portrayal. The series balances humor, drama, and slice-of-life elements, offering a comprehensive look at the joys and struggles of being part of a niche community. Through its exploration of identity, relationships, and the evolving nature of fandom, "Genshiken" provides an engaging and insightful narrative that resonates with both otaku and general audiences.