"Nyō Dō?" is a manga series that blends elements of comedy, romance, and supernatural themes. The story centers around a young man named Kōichi, who unexpectedly inherits a traditional Japanese inn from his late grandmother. Upon arriving at the inn, he discovers that it is inhabited by a group of yōkai, or supernatural beings, who have been living there for generations. These yōkai include a mischievous fox spirit, a reserved and elegant snow woman, and a boisterous kappa, among others. Initially overwhelmed by the bizarre situation, Kōichi gradually adapts to his new role as the innkeeper and begins to form bonds with the yōkai.

The narrative explores Kōichi's efforts to manage the inn while navigating the challenges posed by its supernatural residents. Each chapter often introduces new yōkai or human guests, leading to a series of comedic and heartwarming interactions. The yōkai, while initially appearing as obstacles, reveal their own unique personalities and backstories, adding depth to the story. Kōichi's growing understanding of their world and his willingness to coexist with them form the emotional core of the series.

Romantic undertones emerge as Kōichi develops a close relationship with one of the yōkai, particularly the snow woman, whose aloof demeanor gradually softens as she becomes more attached to him. This dynamic is balanced by the comedic antics of the other yōkai, who often create chaotic situations that Kōichi must resolve. The series also delves into themes of tradition versus modernity, as Kōichi attempts to preserve the inn's heritage while adapting to contemporary expectations.

The plot is episodic in nature, with each chapter presenting a self-contained story that contributes to the overarching narrative of Kōichi's journey as an innkeeper. The yōkai's interactions with human guests often serve as a vehicle for exploring cultural folklore and moral lessons, blending humor with moments of introspection. As the series progresses, Kōichi's role evolves from a reluctant caretaker to a dedicated protector of the inn and its inhabitants, highlighting his personal growth and the deepening bonds between humans and yōkai.