After Luffy as the new Yonkou reaches Egghead Island, he meets Dr. Vegapunk, who is pursued by the World Government for his research on the forbidden history. The CP-0 and Admiral Kizaru receive orders to eliminate Vegapunk. At the same time, the betrayal of Vegapunk's satellite York destabilizes the situation, while a massive Marine fleet – led by Kizaru and Saint Saturn – surrounds the island.

Parallel to this, a global earthquake shakes the world, linked to the mysterious disappearance of the kingdom of Lulusia and rising sea levels. The news also reports on Garp’s disappearance on Pirate Island and an alleged hostage-taking of Vegapunk by the Straw Hat crew.

On Egghead, Luffy and his crew plan their escape with Vegapunk, using York as a bargaining chip, and must stand their ground against the overwhelming Marine forces and the Seraphim. The episode ends with the question of whether the Straw Hats can leave the besieged Egghead, while the Marine prepares its attack.